Immunohistochemical profile of carcinoma breast and its association with clinicopathological features: a single institutional experience

Background: Breast cancer is a systemic disease which has different biological subtypes with vast natural history, clinical presentation, various pathological types and molecular features impact on prognostic profile outcome. Present study aims to evaluate correlation of receptor status (ER, PR HER 2neu) other tumor characteristics.Methods: The present was prospective observational 50 breast patients conducted from January 2020 June 2021 in surgical unit the department general surgery at MDM hospital attached Dr. S. N. medical college, Jodhpur, Rajasthan.Results: Most common age group 41-50 years 38% cases. Majority were females (49, 98%). 88% cases had invasive duct carcinoma. ER, 2neu positivity statistically significant (p<0.0001), histological grade (p<0.0001) size (p=0.04). negative ER (p<0.05).Conclusions: Immunohistochemistry (IHC) markers PR, are positively correlated increasing age, size, positive axillary lymph nodes, also there between overexpression hormone PR) negativity population.